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Polymorphisms in homologous recombination repair genes and the risk and survival of breast cancer
Author(s) -
Liao YuHuang,
Ren JunTing,
Zhang Wei,
Zhang ZhengZheng,
Lin Ying,
Su FengXi,
Jia WeiHua,
Tang LuYing,
Ren ZeFang
Publication year - 2017
Publication title -
the journal of gene medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 91
eISSN - 1521-2254
pISSN - 1099-498X
DOI - 10.1002/jgm.2988
Subject(s) - homologous recombination , breast cancer , homologous chromosome , recombination , gene , genetics , biology , dna repair , cancer
Background Immunoglobulin (Ig)A antibody of Epstein–Barr virus (EBV) was found to associate with breast cancer (BC), whereas IgA positivity was related to a series of genetic markers in the genes of homologous recombination repair system (HRRs). We assessed the associations of the polymorphisms in HRR genes with the risk and survival of BC. Methods A case–control study was conducted with 1551 bc cases and 1605 age‐matched healthy controls between October 2008 and March 2012 in the Guangzhou Breast Cancer Study (GZBCS), China, and the case population were followed up until 31 January 2016. Five single nucleotide polymorphisms of candidate genes in HRR system were genotyped. Odds ratios (ORs) and hazards ratios (HRs) were calculated using multivariate logistic regression and Cox proportional hazards regression to estimate the risk and prognostic effect, respectively. Results RFC1 rs6829064 (AA) was associated with an increased BC risk [OR = 1.35; 95% confidence interval (CI) = 1.06–1.73] compared to the wild genotype (GG). NRM rs1075496 (GT/TT versus GG) was associated with a worse progression‐free survival (PFS) and the HR was 1.34 (95% CI = 1.01–1.78), particularly among advanced patients. LIG3 rs1052536 (CT/TT versus CC) was associated with a better PFS and the HR was 0.70 (95% CI = 0.53–0.93). However, RAD54L rs1710286 and RPA1 rs11078676 were not observed to be associated with either the risk or survival of BC. Conclusions The findings of the present study suggest that the polymorphisms in HRR genes were associated with BC risk ( RFC1 rs6829064) and prognosis ( NRM rs1075496 and LIG3 rs1052536), whereas RAD54L rs1710286 and RPA1 rs11078676 had null associations with BC.