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ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population
Author(s) -
Yu Jianzhong,
Zhou Feng,
Luo Dong,
Wang Nianzhen,
Zhang Chong,
Jin Tianbo,
Liang Xiongfei,
Yu Dan
Publication year - 2017
Publication title -
the journal of gene medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 91
eISSN - 1521-2254
pISSN - 1099-498X
DOI - 10.1002/jgm.2937
Subject(s) - single nucleotide polymorphism , haplotype , medicine , ischemic stroke , logistic regression , stroke (engine) , allele , population , genotype , oncology , genetics , gene , biology , ischemia , mechanical engineering , environmental health , engineering
Background Ischemic stroke is one of the most common diseases with a high burden of neurological deficits, disability and death. Zinc finger protein 208 ( ZNF208 ) was found to be involved in coronary heart disease, although little information is available about its association with ischemic stroke. We performed the present case–control study to clarify the association between single‐nucleotide polymorphisms (SNPs) within ZNF208 and the risk of ischemic stroke in a southern Chinese Han population. Methods A total of 799 subjects (400 cases and 399 healthy controls) were enrolled in the present study. Five SNPs within ZNF208 gene were selected and genotyped using Sequenom MassARRY technology (Sequenom, Inc., San Diego, CA, USA). Data management and statistical analyses were conducted using Sequenom Typer, version 4.0, and a chi‐squared test, as well as unconditional logistic regression. Results Statistical results showed that three variants were associated with the risk of ischemic stroke under allele models (rs2188971, rs2188972, rs8103163 and rs7248488). The variant rs2188972 was also associated with the risk of ischemic stroke in a recessive model after adjustment for age and sex. Haplotype analysis suggested that a significant difference existed between the A rs2188972 T rs2188971 A rs8103163 A rs7248488 haplotype and the risk of ischemic stroke, although this disappeared after adjustment for sex and age. Conclusions The results obtained in the present study indicate a potential association between ZNF208 variants and the risk of ischemic risk in a southern Chinese Han population.