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CYP gene family variants as potential protective factors in drug addiction in Han Chinese
Author(s) -
Zhang Hongxing,
Yang Qi,
Zheng Wenkai,
Ouyang Yongri,
Yang Min,
Wang Fengjiao,
Jin Tianbo,
Zhang Ji,
Wang Zhenyuan
Publication year - 2016
Publication title -
the journal of gene medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 91
eISSN - 1521-2254
pISSN - 1099-498X
DOI - 10.1002/jgm.2887
Subject(s) - single nucleotide polymorphism , genotyping , addiction , genetics , snp , allele , genotype , odds ratio , genetic model , biology , minor allele frequency , pharmacogenetics , medicine , gene , psychiatry
There is growing evidence that genetic factors also contribute to drug addiction. The human cytochrome P450 has shown special interest because of pharmacokinetic variation in different individuals and populations, which is largely determined by the relevant genes. The present study aimed to investigate the polymorphism of the CYP/addicts relationship.