Open AccessCumulative risk of developing a new symptom in patients with primary biliary cholangitis and its impact on prognosis
Author(s) -
Kimura Naruhiro,
Setsu Toru,
Arao Yoshihisa,
Sakai Norihiro,
Watanabe Yusuke,
Abe Hiroyuki,
Kamimura Hiroteru,
Sakamaki Akira,
Yokoo Takeshi,
Kamimura Kenya,
Tsuchiya Atsunori,
Osaki Akihiko,
Igarashi Kentarou,
Waguri Nobuo,
Yanagi Masahiko,
Takahashi Toru,
Sugitani Soichi,
Kobayashi Yuka,
Takamura Masaaki,
Yoshikawa Akira,
Ishikawa Toru,
Yoshida Toshiaki,
Watanabe Toshiaki,
Bannai Hitoshi,
Kubota Tomoyuki,
Funakoshi Kazuhiro,
Wakabayashi Hiroto,
Kurita So,
Ogata Norio,
Watanabe Masashi,
Mita Yuhsaku,
Mori Shigeki,
Sugiyama Motoya,
Miyajima Toru,
Takahashi Sumio,
Sato Shuichi,
Ishizuka Kisei,
Ohta Hironobu,
Aoyagi Yutaka,
Terai Shuji
Publication year - 2022
Publication title -
jgh open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 8
ISSN - 2397-9070
DOI - 10.1002/jgh3.12789
Subject(s) - medicine , hazard ratio , confidence interval , propensity score matching , proportional hazards model , quality of life (healthcare) , logistic regression , survival analysis , gastroenterology , nursing
Background and Aim Symptoms of primary biliary cholangitis (PBC) frequently impair one's quality of life (QOL). Nonetheless, with improved treatment, the prognosis of PBC also improves. QOL plays an important role in patients with PBC. In this study, we aimed to reevaluate the transition of new symptom development in PBC and its predictive factors. Methods This retrospective multicenter study enrolled 382 patients with PBC for symptom analysis. The impact of a newly developed symptom on PBC prognosis was investigated by Kaplan–Meier analysis with propensity score matching and logistic progression analysis. Results The cumulative risk of developing a new symptom after 10 and 20 years of follow‐up was 7.6 and 28.2%, and specifically that of pruritus, which was the most common symptom, was 6.7 and 23.3%, respectively. In Cox hazard risk analysis, serum Alb level (hazard ratio [HR], 1.097; 95% confidence interval [CI], 1.033–1.165; P = 0.002), the serum D‐Bil level (HR, 6.262; 95% CI, 2.522–15.553, P < 0.001), and Paris II criteria (HR, 0.435; 95% CI, 0.183–1.036; P = 0.037) were significant independent predictors of a new symptom. Kaplan–Meier analysis showed that the overall survival and liver‐related death were not significant between patients with and without a new symptom. Conclusion The cumulative risk of new symptom development is roughly 30% 20 years after diagnosis and could be predicted by factors including serum albumin levels, serum D‐Bil level, and Paris II criteria.