Open AccessRare complication of hepatocellular carcinoma in Wilson's disease
Author(s) -
OhkoshiYamada Marina,
Kamimura Kenya,
Kamimura Hiroteru,
Terai Shuji
Publication year - 2021
Publication title -
jgh open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 8
ISSN - 2397-9070
DOI - 10.1002/jgh3.12648
Subject(s) - hepatocellular carcinoma , complication , wilson's disease , medicine , infiltration (hvac) , pathology , disease , immunohistochemistry , gastroenterology , cancer research , physics , thermodynamics
Abstract The complication of hepatocellular carcinoma (HCC) in Wilson's disease is rare. Wilson's disease treatment using D‐penicillamine (DPA) is useful to prevent HCC occurrence; however, it also causes iron accumulation and synergistic radical formation in the liver, which may enhance carcinogenesis. Reported herein is a case of HCC in Wilson's disease treated with DPA for 36 years. The tumor was surgically resected and histologically diagnosed with moderately differentiated HCC surrounded by cirrhotic tissue with fatty infiltration. Rhodanine staining revealed a slight positively stained area in both tumor and surrounding tissues. Information obtained from this case and literature review highlight the feature of HCC in Wilson's disease.