Open AccessJaundice, hepatosplenomegaly, and portal lymphadenopathy in a middle‐aged female: Is it lymphoma?
Author(s) -
Elford Alexander T,
Dwyer Jeremy P,
Fanning Scott B
Publication year - 2020
Publication title -
jgh open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 8
ISSN - 2397-9070
DOI - 10.1002/jgh3.12211
Subject(s) - hepatosplenomegaly , medicine , jaundice , asymptomatic , primary biliary cirrhosis , liver biopsy , generalized lymphadenopathy , gastroenterology , constitutional symptoms , lymphoma , biopsy , radiology , disease
Primary biliary cholangitis is a rare liver disease which often progresses to cirrhosis. It can be difficult to diagnose as patients are often asymptomatic initially or merely complain of fatigue or pruritus. We describe the case of a 56‐year‐old female who presented with a 2‐month history of painless jaundice and constitutional symptoms. Computed tomography scan showed massive hepatosplenomegaly with abdominal lymphadenopathy. Liver biopsy and a strongly positive antimitochondrial antibody titer confirmed the diagnosis of primary biliary cholangitis.