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Clinical background factors affecting outcomes of Helicobacter pylori eradication therapy in primary care
Author(s) -
Yokota Nozomi,
Ae Ryusuke,
Amenomori Masaki,
Kitagawa Koji,
Nakamura Takuya,
Yokota Tetsuro,
Masato Kato,
Sasahara Teppei,
Matsubara Yuri,
Kosami Koki,
Nakamura Yoshikazu
Publication year - 2019
Publication title -
journal of general and family medicine
Language(s) - English
Resource type - Journals
ISSN - 2189-7948
DOI - 10.1002/jgf2.245
Subject(s) - medicine , helicobacter pylori , primary care , helicobacter infections , intensive care medicine , family medicine
Objective Few studies have reported the influence of clinical background factors on the outcome of Helicobacter pylori eradication therapy in primary care practice. We aimed to determine which clinical background factors influence the outcome of eradication therapy in a primary care setting. Methods This was a retrospective study of patients who received H pylori eradication therapy at Higashiohmi City Gamo Medical Center, Shiga, Japan, from January 2012 to December 2015. We investigated clinical background factors associated with success, failure, and self‐interruption of H pylori eradication therapy: patients’ age, gender, first‐ or second‐line treatment, reasons for receiving gastroenterological endoscopic examination, method of drug administration, and attending physicians’ age and their specialties. Results There were 369 patients (208 females, 161 male), with a mean age of 59 years (range 30‐88 years). The middle‐aged group (50‐69 years) was associated with successful eradication therapy compared with the young group (30‐49 years). The elderly group (>70 years) was associated with eradication therapy failure compared with the middle‐aged group. The young group was associated with self‐interruption of eradication therapy. There was a marginally significant association between male patients and self‐interruption. Older attending physicians (>50 years) were also associated with failure compared with younger physicians. There was no difference in outcome of eradication therapy between generalists and gastroenterology specialists. Conclusion We have identified clinical factors associated with success, failure, and self‐interruption of H pylori eradication therapy in a primary care setting.

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