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Dynamical patterning modules and network motifs as joint determinants of development: Lessons from an aggregative bacterium
Author(s) -
GuzmánHerrera Alejandra,
Arias Del Angel Juan A.,
RiveraYoshida Natsuko,
Benítez Mariana,
Franci Alessio
Publication year - 2021
Publication title -
journal of experimental zoology part b: molecular and developmental evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 63
eISSN - 1552-5015
pISSN - 1552-5007
DOI - 10.1002/jez.b.22946
Subject(s) - multicellular organism , myxococcus xanthus , organism , identification (biology) , process (computing) , network motif , biology , evolutionary biology , computational biology , computer science , biological network , gene , ecology , genetics , mutant , operating system
Development and evolution are dynamical processes under the continuous control of organismic and environmental factors. Generic physical processes, associated with biological materials and certain genes or molecules, provide a morphological template for the evolution and development of organism forms. Generic dynamical behaviors, associated with recurring network motifs, provide a temporal template for the regulation and coordination of biological processes. The role of generic physical processes and their associated molecules in development is the topic of the dynamical patterning module (DPM) framework. The role of generic dynamical behaviors in biological regulation is studied via the identification of the associated network motifs (NMs). We propose a joint DPM–NM perspective on the emergence and regulation of multicellularity focusing on a multicellular aggregative bacterium, Myxococcus xanthus . Understanding M. xanthus development as a dynamical process embedded in a physical substrate provides novel insights into the interaction between developmental regulatory networks and generic physical processes in the evolutionary transition to multicellularity.