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Epigenetics, plasticity, and evolution: How do we link epigenetic change to phenotype?
Author(s) -
Duncan Elizabeth J.,
Gluckman Peter D.,
Dearden Peter K.
Publication year - 2014
Publication title -
journal of experimental zoology part b: molecular and developmental evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 63
eISSN - 1552-5015
pISSN - 1552-5007
DOI - 10.1002/jez.b.22571
Subject(s) - epigenetics , biology , phenotypic plasticity , dna methylation , histone , phenotype , organism , epigenesis , genetics , regulation of gene expression , gene expression , epigenetic regulation of neurogenesis , gene , computational biology , evolutionary biology
Epigenetic mechanisms are proposed as an important way in which the genome responds to the environment. Epigenetic marks, including DNA methylation and Histone modifications, can be triggered by environmental effects, and lead to permanent changes in gene expression, affecting the phenotype of an organism. Epigenetic mechanisms have been proposed as key in plasticity, allowing environmental exposure to shape future gene expression. While we are beginning to understand how these mechanisms have roles in human biology and disease, we have little understanding of their roles and impacts on ecology and evolution. In this review, we discuss different types of epigenetic marks, their roles in gene expression and plasticity, methods for assaying epigenetic changes, and point out the future advances we require to understand fully the impact of this field. J. Exp. Zool. (Mol. Dev. Evol.) 322B: 208–220, 2014 . © 2014 The Authors. J. Exp. Zool. (Mol. Dev. Evol.) published by Wiley Periodicals, Inc.