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The role of domain shuffling in the evolution of signaling networks
Author(s) -
Di Roberto Raphael B.,
Peisajovich Sergio G.
Publication year - 2014
Publication title -
journal of experimental zoology part b: molecular and developmental evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 63
eISSN - 1552-5015
pISSN - 1552-5007
DOI - 10.1002/jez.b.22551
Subject(s) - shuffling , novelty , cognitive science , domain (mathematical analysis) , evolutionary biology , biological evolution , biology , computer science , epistemology , philosophy , genetics , psychology , mathematical analysis , theology , mathematics , programming language
In a seminal paper entitled “Evolution and Tinkering,” François Jacob affirmed that: “Novelties come from previously unseen association of old material. To create is to recombine” [Jacob F. (1977) Science 196:1161–1166]. In the 35 years that have passed since Jacob's insight, we have amassed enough data to actually shed light on many of the molecular mechanisms that enable evolution to create novelty by simply recombining what existed already. In this review, we will succinctly discuss the role that the recombination of protein domains has in the evolution of signaling networks, drawing from examples provided by diverse disciplines, including bioinformatics, systems and synthetic biology, and laboratory evolution. J. Exp. Zool. (Mol. Dev. Evol.) 322B: 65–72, 2014 . © 2013 Wiley Periodicals, Inc.