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Epithelial‐specific requirement of FGFR2 signaling during tooth and palate development
Author(s) -
Hosokawa Ryoichi,
Deng Xuemei,
Takamori Kazunori,
Xu Xun,
Urata Mark,
Bringas Pablo,
Chai Yang
Publication year - 2009
Publication title -
journal of experimental zoology part b: molecular and developmental evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 63
eISSN - 1552-5015
pISSN - 1552-5007
DOI - 10.1002/jez.b.21274
Subject(s) - fibroblast growth factor , mesenchyme , microbiology and biotechnology , fibroblast growth factor receptor 2 , epithelium , biology , fibroblast growth factor receptor 1 , conditional gene knockout , fgf10 , embryonic stem cell , fibroblast growth factor receptor , fibroblast , mesenchymal stem cell , receptor , cell culture , phenotype , genetics , gene
Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial–mesenchymal tissue interaction. We have generated epithelial‐specific conditional knockout mice targeting Fibroblast growth factor receptor 2 ( Fgfr2 ) to investigate the function of FGF signaling during craniofacial development. K14‐Cre;Fgfr2 fl/fl mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of K14‐Cre;Fgfr2 fl/fl mice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development. J. Exp. Zool. (Mol. Dev. Evol.) 312B:343–350, 2009 . © 2009 Wiley‐Liss, Inc.
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