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Scube1 is expressed during facial development in the mouse
Author(s) -
Xavier Guilheme M.,
Sharpe Paul T.,
Cobourne Martyn T.
Publication year - 2008
Publication title -
journal of experimental zoology part b: molecular and developmental evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 63
eISSN - 1552-5015
pISSN - 1552-5007
DOI - 10.1002/jez.b.21260
Subject(s) - craniofacial , dental papilla , trigeminal ganglion , anatomy , biology , neural tube , neural development , microbiology and biotechnology , gene , medicine , pathology , neuroscience , embryo , odontoblast , genetics , sensory system , dentin
Scube1 encodes a secreted plasma membrane‐associated protein characterized by a N‐terminal signal peptide sequence, multiple EGF domains, a N‐linked glycosylated spacer region and a C‐terminal CUB region. Here, we describe expression of the mouse Scube1 gene during early craniofacial development. Transcripts were identified in the nervous system, within the ventral neural tube, telencephalon and trigeminal ganglion. In addition, strong regionally restricted expression was found in the facial processes, including the medial and lateral nasal processes, maxilla and mandible, and caudal pharyngeal arches. During tooth development, Scube1 localized to the dental papilla of both incisor and molar teeth. Together, these data suggest a potential role for Scube1 during early craniofacial development. J. Exp. Zool. (Mol. Dev. Evol.) 312B:518–524, 2009 . © 2008 Wiley‐Liss, Inc.