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RNAs everywhere: genome‐wide annotation of structured RNAs
Author(s) -
Backofen Rolf,
Bernhart Stephan H.,
Flamm Christoph,
Fried Claudia,
Fritzsch Guido,
Hackermüller Jörg,
Hertel Jana,
Hofacker Ivo L.,
Missal Kristin,
Mosig Axel,
Prohaska Sonja J.,
Rose Dominic,
Stadler Peter F.,
Tanzer Andrea,
Washietl Stefan,
Will Sebastian
Publication year - 2006
Publication title -
journal of experimental zoology part b: molecular and developmental evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 63
eISSN - 1552-5015
pISSN - 1552-5007
DOI - 10.1002/jez.b.21130
Subject(s) - annotation , computational biology , genome , biology , genome project , microrna , field (mathematics) , computer science , genetics , gene , mathematics , pure mathematics
Starting with the discovery of microRNAs and the advent of genome‐wide transcriptomics, non‐protein‐coding transcripts have moved from a fringe topic to a central field research in molecular biology. In this contribution we review the state of the art of “computational RNomics”, i.e., the bioinformatics approaches to genome‐wide RNA annotation. Instead of rehashing results from recently published surveys in detail, we focus here on the open problem in the field, namely (functional) annotation of the plethora of putative RNAs. A series of exploratory studies are used to provide non‐trivial examples for the discussion of some of the difficulties. J. Exp. Zool. (Mol. Dev. Evol.) 308B, 2007 . © 2006 Wiley‐Liss, Inc.