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Evolution of microRNAs located within Hox gene clusters
Author(s) -
Tanzer Andrea,
Amemiya Chris T.,
Kim ChangBae,
Stadler Peter F.
Publication year - 2005
Publication title -
journal of experimental zoology part b: molecular and developmental evolution
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 63
eISSN - 1552-5015
pISSN - 1552-5007
DOI - 10.1002/jez.b.21021
Subject(s) - hox gene , biology , microrna , gene , genetics , intergenic region , gene cluster , regulation of gene expression , rna , non coding rna , transcription (linguistics) , gene expression , computational biology , evolutionary biology , genome , linguistics , philosophy
MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss. J. Exp. Zool. (Mol. Dev. Evol.) 304B: 1–10, 2005 . © 2005 Wiley‐Liss, Inc.