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Embryotoxicity characterization of the flame retardant tris(1‐chloro‐2‐propyl)phosphate (TCPP) in the invertebrate chordate Ciona intestinalis
Author(s) -
Mercurio Silvia,
Messinetti Silvia,
Manenti Raoul,
Ficetola Gentile Francesco,
Pennati Roberta
Publication year - 2021
Publication title -
journal of experimental zoology part a: ecological and integrative physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.834
H-Index - 11
eISSN - 2471-5646
pISSN - 2471-5638
DOI - 10.1002/jez.2446
Subject(s) - ciona intestinalis , marine invertebrates , phosphate , fire retardant , invertebrate , environmental chemistry , tris , benthic zone , biology , biodegradation , pollutant , chordate , chemistry , ecology , biochemistry , organic chemistry , vertebrate , gene
Tris(1‐chloro‐2‐propyl)phosphate (TCPP) is the most common chlorinated organophosphorus flame retardant in seawater. Due to its chemical features and abundance, TCPP has been classified as a high hazard, and restrictions of use have been set in multiple countries. Despite TCPP being highly present in the marine environment, only a few studies have explored the TCPP impact on the development of marine invertebrates. Ascidians are important invertebrate members of benthic marine communities and reliable model systems for ecotoxicological research. The aim of this study was to assess the adverse effects of TCPP exposure on the embryogenesis of the ascidian Ciona intestinalis . Our results showed that this pollutant affected both muscles and nervous system development. Malformations appeared similar to those reported in other animal models for other flame retardants, suggesting that these molecules could share a common mechanism of action and induce a mixture effect when simultaneously present in the aquatic environment even at sub‐teratogenic concentrations.