Open AccessAre supermeres a distinct nanoparticle?
Author(s) -
Jeppesen Dennis K.,
Zhang Qin,
Franklin Jeffrey L.,
Coffey Robert J.
Publication year - 2022
Publication title -
journal of extracellular biology
Language(s) - English
Resource type - Journals
ISSN - 2768-2811
DOI - 10.1002/jex2.44
Subject(s) - nanoparticle , ultracentrifuge , population , pellet , analytical ultracentrifugation , nanotechnology , chemistry , materials science , chromatography , medicine , environmental health , composite material
We have recently reported the discovery of a new distinct nanoparticle by ultracentrifugation of the supernatant of exomeres at 376,000 x g for 16 hours. We termed the resulting pellet, supermeres (supernatant of exomeres). The Witwer team raised the legitimate question that these two membraneless nanoparticles may arise from a continuous population of extracellular particles. We have reviewed our data here and present additional analyses that reinforce supermeres as distinct nanoparticles.