Premium
Phytofabrication of cobalt oxide nanoparticles from Rhamnus virgata leaves extract and investigation of different bioactivities
Author(s) -
Abbasi Banzeer Ahsan,
Iqbal Javed,
Khan Zaibunisa,
Ahmad Riaz,
Uddin Siraj,
Shahbaz Amir,
Zahra Syeda Anber,
Shaukat Muzzafar,
Kiran Farmeen,
Kanwal Sobia,
Mahmood Tariq
Publication year - 2021
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.23577
Subject(s) - nuclear chemistry , chemistry , fourier transform infrared spectroscopy , amastigote , biocompatibility , cytotoxicity , nanoparticle , raman spectroscopy , antibacterial activity , in vitro , nanotechnology , biochemistry , materials science , organic chemistry , leishmania , biology , bacteria , chemical engineering , physics , optics , engineering , parasite hosting , world wide web , computer science , genetics
The tunable cobalt oxide nanoparticles (CoONPs) are produced due to the phytochemicals present in Rhamnus virgata (RhV) leaf extract which functions as reducing and stabilization agents. The synthesis of CoONPs was confirmed using different analytical techniques: UV–Vis spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), dynamics light scatterings (DLS), Fourier‐transform infrared spectroscopy (FTIR), energy dispersive X‐ray, and Raman spectroscopy analyses. Furthermore, multiple biological activities were performed. Significant antifungal and antibacterial potentials have been reported. The in vitro cytotoxic assays of CoONPs revealed strong anticancer activity against human hepatoma HUH‐7 (IC 50 : 33.25 μg/ml) and hepatocellular carcinoma HepG2 (IC 50 : 11.62 μg/ml) cancer cells. Dose‐dependent cytotoxicity potency was confirmed against Leishmania tropica (KMH 23 ); amastigotes (IC 50 : 58.63 μg/ml) and promastigotes (IC 50 : 32.64 μg/ml). The biocompatibility assay using red blood cells (RBCs; IC 50 : 4,636 μg/ml) has confirmed the bio‐safe nature of CoONPs. On the whole, results revealed nontoxic nature of RhV‐CoONPs with promising biological potentials.