Premium
Accurate assessment of nonalcoholic fatty liver disease lesions in liver allograft biopsies by a smartphone platform: A proof of concept
Author(s) -
Cesaretti Manuela,
Gal Jocelyn,
Bouveyron Charles,
Diaspro Alberto,
Fontas Eric,
Antonini Andrea,
Anty Rodolphe,
Iannelli Antonio,
Patouraux Stephanie
Publication year - 2020
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.23478
Subject(s) - nonalcoholic fatty liver disease , gold standard (test) , medicine , liver transplantation , pathology , telepathology , biopsy , fatty liver , transplantation , disease , radiology , telemedicine , health care , economics , economic growth
Macrovesicular steatosis (MS) is a major risk factor for liver graft failure after transplantation and pathological microscopic examination of a frozen tissue section remains the gold standard for its assessment. However, the latter requires an experienced in‐house pathologist for correct and rapid diagnosis as well as specific equipment that is not always available. Smartphones, which are must‐have tools for everyone, are very suitable for incorporation into promising technology to generate moveable diagnostic tools as for telepathology. The study aims to compare the microscopic assessment of nonalcoholic fatty liver disease (NAFLD) spectrum in liver allograft biopsies by a smartphone microscopy platform (DIPLE device) to standard light microscopy. Forty‐two liver graft biopsies were evaluated in transmitted light, using an iPhone X and the microscopy platform. A significant correlation was reported between the two different approaches for graft MS assessment (Spearman's correlation coefficient: r = .93; p < .001) and for steatohepatitis feature ( r = .56; p < .001; r = .45; p < .001). Based on these findings, a smartphone integrated with a cheap microscopy platform can achieve adequate accuracy in the assessment of NAFLD in liver graft and could be used as an alternative to standard light microscopy when the latter is unavailable.