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Resveratrol treatment of spinal cord injury in rat model
Author(s) -
Liu Xuehong,
Botchway Benson O.A.,
Tan Xiaoning,
Zhang Yong,
Fang Marong
Publication year - 2019
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.23171
Subject(s) - spinal cord injury , resveratrol , therapeutic effect , medicine , methylprednisolone , rat model , neuroprotection , spinal cord , therapeutic approach , pharmacology , anesthesia , disease , psychiatry
Abstract Spinal cord injury (SCI) is catastrophic and can culminate in disability and death. The routine therapy employed in early stages of SCI currently entails surgical procedures combined with high doses of methylprednisolone (MP). MP is highly controversial for the lack of consensus on its true therapeutic effects. Resveratrol (RES) has recently been recognized as a potential and novel therapeutic drug in SCI. Herein, we investigated the effect of RES in a SCI rat‐model and found significant improvement in Basso–Beattie–Bresnahan scores. Results obtained from histological, immunohistochemistry, and ultra‐structural examinations evidenced the tremendous treatment effect of RES. On the basis of our experimental results, we hypothesize that RES could serve as an effective SCI therapeutic with prolong treatment time following injury.