Premium
Changes in nail keratin observed by Raman spectroscopy after Nd:YAG laser treatment
Author(s) -
Shin Min Kyung,
Kim Tae In,
Kim Wan Sun,
Park HunKuk,
Kim Kyung Sook
Publication year - 2017
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.22734
Subject(s) - nail (fastener) , laser , nail plate , keratin , raman spectroscopy , materials science , dermatology , nail disease , chemistry , optics , medicine , pathology , physics , metallurgy , psoriasis
Abstract Lasers and photodynamic therapy have been considered a convergence treatment for onychomycosis, which is a fungal infection on the nail bed and nail plate. Laser therapies have shown satisfactory results without significant complications for onychomycosis; however, the mechanism of clearing remains unknown. In this work, we investigated changes in the chemical structure of nail keratin induced by Nd:YAG laser using Raman spectroscopy. Toe nails with onychomycosis were treated with 1064 nm Nd:YAG laser. After laser treatment, the disulfide band (490–590 cm −1 ) of nail keratin was rarely observed or was reduced in intensity. The amide I band (1500–1700 cm −1 ) also showed changes induced by the laser. The α‐helical (1652 cm −1 ) structures dominated the β‐sheet (1673 cm −1 ) in nontreated nail, but the opposite phenomenon was observed after laser treatment.