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Atomic force microscopy combined with optical microscopy for cells investigation
Author(s) -
Cascione Mariafrancesca,
de Matteis Valeria,
Rinaldi Rosaria,
Leporatti Stefano
Publication year - 2017
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.22696
Subject(s) - atomic force microscopy , microscopy , fluorescence microscope , nanotechnology , optical microscope , mechanotransduction , scanning ion conductance microscopy , materials science , atomic force acoustic microscopy , chemistry , scanning confocal electron microscopy , optics , fluorescence , magnetic force microscope , scanning electron microscope , physics , biology , composite material , microbiology and biotechnology , magnetization , quantum mechanics , magnetic field
This review reports on the combined use of the atomic force microscopy (AFM) and several type of optical/fluorescence/laser scanning microscopy for investigating cells. It is shown that the hybrid systems of AFM with optical‐derived microscopies enable to study in detail cell surface properties (such as topography), their mechanical properties (e.g., Young's modulus) mechanotransduction phenomena and allow to gain insight into biological‐related pathways and mechanisms in the complex nanoworld of cells. Microsc. Res. Tech. 80:109–123, 2017 . © 2016 Wiley Periodicals, Inc.