Premium
Controlled degradation pattern of hydroxyapatite/calcium carbonate composite microspheres
Author(s) -
Yang Ning,
Zhong Qiwei,
Zhou Ying,
Kundu Subhas C.,
Yao Juming,
Cai Yurong
Publication year - 2016
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.22661
Subject(s) - composite number , biocompatibility , degradation (telecommunications) , materials science , microsphere , calcium carbonate , chemical engineering , calcium , composite material , biomedical engineering , chemistry , metallurgy , telecommunications , computer science , engineering , medicine
Hydroxyapatite (HAP) is widely used in clinic due to its good biocompatibility and osteoconductivity except for its slow degradation speed. In the present study, spherical calcium carbonate (CaCO 3 ) is fabricated in the presence of silk protein sericin, which is transmuted into HAP microsphere in phosphate solution with the assistance of microwave irradiation. The effect of reaction conditions on the conversion of CaCO 3 is investigated including reaction time, chemical composition of phosphate solution, and microwave power to get a series of HAP/CaCO 3 composites. The degradation property of the composites is evaluated in vitro. Results show the degradation speed of the composite with higher HAP content is slower. The degradation rate of the composite could be changed effectively by modulating the proportion of HAP and CaCO 3 . This work provides a feasible method for the preparation of spherical HAP/CaCO 3 composite with controllable degradability. The composite thus obtained may be an ideal material for bone tissue engineering application. Microsc. Res. Tech. 79:518–524, 2016 . © 2016 Wiley Periodicals, Inc.