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Preparation of silk fibroin carriers for controlled release
Author(s) -
Liu Qiang,
Liu Haifeng,
Fan Yubo
Publication year - 2017
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.22606
Subject(s) - fibroin , biocompatibility , self healing hydrogels , drug delivery , nanotechnology , silk , materials science , controlled release , microsphere , regenerative medicine , biomedical engineering , chemistry , chemical engineering , composite material , polymer chemistry , medicine , biochemistry , engineering , metallurgy , cell
Silk fibroin provides a new option for controlled release systems as a result of its excellent biodegradability, biocompatibility, and mechanical properties. As the core material, silk fibroin can be designed and widely used in drug/gene delivery, regenerative medicine, and other biomedical fields. This review focuses on the preparation methods, loading molecules, and applications of silk fibroin‐based controlled release systems including microspheres, microcapsules, films, microparticles, microneedles, liposomes, and hydrogels. These systems provide numerous advantages such as high encapsulation efficiency, avoiding loss of bioactivity and maintaining desirable range without peaks and valleys in comparison to the traditional administration approaches. Microsc. Res. Tech. 80:312–320, 2017. © 2015 Wiley Periodicals, Inc.