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Mouse brain magnetic resonance microscopy: Applications in A lzheimer disease
Author(s) -
Lin Lan,
Fu Zhenrong,
Xu Xiaoting,
Wu Shuicai
Publication year - 2015
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.22489
Subject(s) - genetically modified mouse , disease , magnetic resonance imaging , neuroscience , drug discovery , pathology , transgene , biology , medicine , chemistry , bioinformatics , gene , genetics , radiology
Over the past two decades, various Alzheimer's disease (AD) trangenetic mice models harboring genes with mutation known to cause familial AD have been created. Today, high‐resolution magnetic resonance microscopy (MRM) technology is being widely used in the study of AD mouse models. It has greatly facilitated and advanced our knowledge of AD. In this review, most of the attention is paid to fundamental of MRM, the construction of standard mouse MRM brain template and atlas, the detection of amyloid plaques, following up on brain atrophy and the future applications of MRM in transgenic AD mice. It is believed that future testing of potential drugs in mouse models with MRM will greatly improve the predictability of drug effect in preclinical trials. Microsc. Res. Tech. 78:416–424, 2015 . © 2015 Wiley Periodicals, Inc.