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Immunolocalization of substance P and NK‐1 receptor in hofbauer cells in human normal placenta
Author(s) -
Muñoz Miguel,
Carranza Andrés,
Pavón Antonio,
Anderson George,
Coveñas Rafael
Publication year - 2013
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.22303
Subject(s) - human placenta , placenta , receptor , microbiology and biotechnology , chemistry , andrology , biology , medicine , pregnancy , biochemistry , fetus , genetics
Substance P (SP) after binding to the neurokinin‐1 (NK‐1) receptor regulates many biological functions. Both SP and the NK‐1 receptor are expressed in human normal placenta cells, monocytes, and macrophages. However, to our knowledge, the presence of both SP and the NK‐1 receptor in macrophages of the placenta, the Hofbauer cells, is unknown. We demonstrate by immunohistochemistry in human normal placenta samples the presence of both SP and NK‐1 receptors in the cytoplasm and in the nucleus of Hofbauer cells. The findings suggest a functional role of the SP/NK‐1 receptor system in the physiology and pathophysiology of Hofbauer cells in the human placenta. Microsc. Res. Tech. 76:1310‐1313, 2013 . © 2013 Wiley Periodicals, Inc.