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Response of serum minerals (calcium, phosphate, and magnesium) and endocrine glands (calcitonin cells and parathyroid gland) of wistar rat after chlorpyrifos administration
Author(s) -
Tripathi Sarojni,
Suzuki Nobuo,
Srivastav Ajai Kumar
Publication year - 2013
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.22217
Subject(s) - calcitonin , endocrinology , hypophosphatemia , medicine , calcium , hypomagnesemia , parathyroid gland , chemistry , magnesium , chlorpyrifos , phosphate , parathyroid hormone , biology , biochemistry , organic chemistry , pesticide , agronomy
Wistar rats (male) were daily administered chlorpyrifos at a dose of 5 mg/kg b wt. and 10 mg/kg b wt. and sacrificed on 1st, 2nd, 4th, 6th, and 8th week. In chlorpyrifos exposed rats hypocalcemia, hypophosphatemia and hypomagnesemia were recorded. At later intervals an increased levels of serum calcium and phosphate were observed. The parathyroid glands and calcitonin cells exhibited increased activity which is evident by increased nuclear volume of these cells. Microsc. Res. Tech. 76:673–678, 2013 . © 2013 Wiley Periodicals, Inc.