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Role of parietal and principal gastric mucosa cells in the phenomenon of concentration of aluminum and indium
Author(s) -
Maghraoui Samira,
Ayadi Ahlem,
Audinot JeanNicolas,
Ammar Aouatef Ben,
Jaafoura MohamedHabib,
Hili Ali El,
Migeon HenriNoël,
Tekaya Leila
Publication year - 2012
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.21041
Subject(s) - gastric mucosa , indium , foveolar cell , chemistry , pathology , ultrastructure , vacuole , enterochromaffin like cell , lysosome , osmium , stomach , biophysics , biology , medicine , biochemistry , enzyme , cytoplasm , organic chemistry , ruthenium , catalysis
The subcellular behavior of aluminum and indium, used in medical and industrial fields, was studied in the gastric mucosa and the liver after their intragastric administration to rats, using, two of the most sensitive methods of observation and microanalysis, the transmission electron microscopy, and the secondary ion mass spectrometry. The ultrastructural study showed the presence of electron dense deposits, in the lysosomes of parietal and principal gastric mucosa cells but no loaded lysosomes were observed in the different studied hepatic territories. The microanalytical study allowed the identification of the chemical species present in those deposits as aluminum or indium isotopes and the cartography of their distribution. No modification was observed in control rats tissues. In comparison to previous studies describing the mechanism of aluminum concentration in the gastric mucosa and showing that this element was concentrated in the lysosomes of fundic and antral human gastric mucosa, our study provided additional informations about the types of cells involved in the phenomenon of concentration of aluminum and indium, which are the parietal and the principal cells of the gastric mucosa. Our study demonstrated that these cells have the ability to concentrate selectively aluminum and indium in their lysosomes, as a defensive reaction against intoxication by foreign elements. Microsc. Res. Tech., 2011 © 2011 Wiley Periodicals, Inc.