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Glycogen autophagy
Author(s) -
Kotoulas Othon B.,
Kalamidas Stefanos A.,
Kondomerkos Dimitrios J.
Publication year - 2004
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.20046
Subject(s) - autophagy , vacuole , glycogen , glycogen synthase , microbiology and biotechnology , glycogenolysis , biochemistry , biology , chemistry , cell , cytoplasm , apoptosis
Glycogen autophagy, which includes the sequestration and degradation of cell glycogen in the autophagic vacuoles, is a selective process under conditions of demand for the massive hepatic production of glucose, as in the postnatal period. It represents a link between autophagy and glycogen metabolism. The formation of autophagic vacuoles in the hepatocytes of newborn animals is spatially and biochemically related to the degradation of cell glycogen. Many molecular elements and signaling pathways including the cyclic AMP/cyclic AMP‐dependent protein kinase and the phosphoinositides/TOR pathways are implicated in the control of this process. These two pathways may converge on the same target to regulate glycogen autophagy. Microsc. Res. Tech. 64:10–20, 2004. © 2004 Wiley‐Liss, Inc.