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Ultrastructural features of bone marrow cells from patients with acquired sideroblastic anemia
Author(s) -
Djaldetti Meir,
Bergman Michael,
Salman Hertzel,
Cohen Amos M.,
Bessler Hanna
Publication year - 2004
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.20024
Subject(s) - ultrastructure , vacuole , sideroblastic anemia , cytoplasm , mitochondrion , pathology , bone marrow , haematopoiesis , anemia , electron microscope , phagocytosis , red cell , microbiology and biotechnology , biology , chemistry , medicine , stem cell , physics , optics
The ultrastructural findings of the bone marrow cells from 15 patients with acquired sideroblastic anemia are presented. The red cell precursors from all patients showed the presence of electron‐dense material in the mitochondria, representing most probably iron deposits. A great number of these mitochondria were completely destroyed. The erythropoietic precursors from one of the patients showed markedly elongated mitochondria that measured up to 3 μm. In addition numerous cytoplasmic vacuoles were observed. The red cell precursors from 60% of the patients showed signs of dyserythropoiesis, such as incomplete nuclear division and nuclear distortion. The polymorphonuclears from 47% of the patients presented nuclear abnormalities expressed as nuclear bridges, appendices, and blebs. In addition, phagocytosis of red blood cells was observed. The results of the study underline the advantages of the transmission electron microscope examination in visualization of intricate alterations in hematopoietic cells that cannot be detected with a light microscope. Microsc. Res. Tech. 63:155–158, 2004. © 2004 Wiley‐Liss, Inc.