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Alveolar macrophage–T cell interactions during Th1‐type sarcoid inflammation
Author(s) -
Agostini Carlo,
Facco Monica,
Chilosi Marco,
Semenzato Gianpietro
Publication year - 2001
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.1094
Subject(s) - sarcoidosis , macrophage , immunology , chemokine , pathogenesis , immune system , disease , inflammation , granuloma , alveolar macrophage , granuloma formation , biology , medicine , pathology , genetics , in vitro
Sarcoidosis is an immunomediated, multisystem disorder of unknown cause(s) characterized by a heightened Th1 immune response that leads to an uncontrolled granuloma formation at sites of disease activity. The past few years have seen outstanding advances in the understanding of immunological and molecular events involved in the pathogenesis of this disease. The idea is that several cytokines and chemokines, which are secreted at sites of disease activity, participate in granuloma formation. This paper describes recent data that have clarified some of the events that govern the development of the hypersensitivity reaction during sarcoidosis. In particular, we will review recent evidence indicating that a complex relationship exists between the macrophage/lymphocyte cellular axis and the tissue networks of cytokines. Microsc. Res. Tech. 53:278–287, 2001. © 2001 Wiley‐Liss, Inc.