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Interpreting MHC class I expression and class I/class II reciprocity in the CNS: Reconciling divergent findings
Author(s) -
Lampson Lois A.
Publication year - 1995
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.1070320402
Subject(s) - class (philosophy) , mhc class i , reciprocity (cultural anthropology) , mhc class ii , biology , genetics , major histocompatibility complex , psychology , epistemology , social psychology , philosophy , immune system
MHC‐restricted T cells are thought to contribute to clinical demyelination in MS and other circumstances. The step‐by‐step mechanisms involved and ways of controlling them are still being defined. Identification of the MHC + cells in the CNS in situ has been controversial. This chapter reviews MHC expression in neural tissue, including normal, pathological, experimental, and developing tissue in situ and isolated cells in vitro. A basic pattern is defined, in which MHC expression is limited to nonneural cells and strongest class I and II expression are on different cell types. Variations from the basic pattern are reviewed. Ways of reconciling divergent findings are discussed, including the use of “mock tissue” to help choose between technical and biological bases for divergent findings, the potential contribution of internal antigen to the in situ staining patterns, and the possibility that class I upregulation is actively suppressed in situ. Functional implications of the observed patterns of MHC expression and ways of confirming the function of each MHC + cell type in situ are described. It is suggested that modulating MHC expression in different cell types at different times or in different directions might be desirable. © 1995 Wiley‐Liss, Inc.