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Analysis of cell death and cell proliferation in embryonic stages, normal adult, and aging prostates in human and animals
Author(s) -
Sensibar Julia A.
Publication year - 1995
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.1070300409
Subject(s) - programmed cell death , cell growth , microbiology and biotechnology , biology , stroma , cell , epithelium , cell division , prostate , embryonic stem cell , cancer research , apoptosis , immunology , cancer , immunohistochemistry , genetics , gene
Homeostasis in the prostate is recognized to be maintained by a complex interplay between the opposing actions of cell proliferation and Cell death. Growth regulatory factors that promote or inhibit cell proliferation and promote cellular death have been identified in the prostate. The integration of these forces involves cellular cooperation between the prostatic stroma and epithelium. Hormone‐regulated production of growth regulatory factors by one cell type may determine growth stimulation, inhibition, or cell death in a reciprocal cell partner. Imbalance between net cell proliferation and net cell death rates may result in abnormal growth leading to BPH. Additional study of the growth regulatory factors associated with distal vs. proximal epithelial cells and stroma and comparison of growth factor expression by the neonatal, postnatal growing, adult quiescent, and aging prostates will likely provide further insight into the regulation of prostate cell division and death. © 1995 Wiley‐Liss, Inc.