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Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes
Author(s) -
Hunziker Ernst B.
Publication year - 1994
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.1070280606
Subject(s) - chondrocyte , mechanism (biology) , microbiology and biotechnology , bone growth , bone formation , bone development , biology , cartilage , anatomy , endocrinology , philosophy , epistemology
Abstract Growth plate chondrocytes play a pivotal role in promoting longitudinal bone growth. The current review represents a brief survey of the phenomena involved in this process at the cellular level; it delineates the contributions made by various activities during the course of the chondrocyte life cycle, notably proliferation and hypertrophy, and illustrates how the relative contributions may be modulated according to the particular needs of an organism at critical phases of growth. The cellular mechanisms by which a few well characterized growth‐promoting substances exert their influences are discussed in the light of recent findings pertaining to epiphyseal plate chondrocytes in vivo. © 1994 Wiley‐Liss, Inc.