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The glomerular basement membrane in lupus nephritis
Author(s) -
Bruijn Jan A.
Publication year - 1994
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.1070280303
Subject(s) - lupus nephritis , glomerular basement membrane , basement membrane , nephritis , pathology , renal biopsy , systemic lupus erythematosus , renal pathology , disease , medicine , glomerulonephritis , immunology , immunofluorescence , biopsy , kidney , antibody
Abstract Systemic lupus erythematosus is a disease that is particularly suited for studies of glomerular basement membrane pathology. Classification of the renal pathology of lupus nephritis is usually based on light microscopic features, combined with immunofluorescence findings and electron microscopic alterations. Study of renal biopsy helps to distinguish potentially reversible and irreversible disease, and to estimate prognosis of patients with lupus nephritis. Moreover, studies of human disease, as well as the availability of animal models and in vitro cell culture systems employing biochemical and molecular biological studies of extracellular matrix, have led to a considerable increase in knowledge of the pathogenetic events underlying derangements of the glomerular basement membrane in lupus nephritis. © 1994 Wiley‐Liss, Inc.