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Plasticity of cell organization during differentiation of normal and oncogene transformed granulosa cells
Author(s) -
Amsterdam A.,
Aharoni D.
Publication year - 1994
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.1070270205
Subject(s) - microbiology and biotechnology , plasticity , biology , oncogene , cellular differentiation , cell , genetics , cell cycle , gene , materials science , composite material
Granulosa cells, which nurse the oocyte and serve as a major source for estradiol and progesterone production, undergo major morphological changes which correlate very well with modulation of their steroidogenic capacity. These include changes in intercellular contacts and communication, in cell membrane receptors, and in the development and organization of organelles associated with steroidogenesis (i.e., mitochondria, smooth endoplasmic reticulum, lipid droplets, and lysosomes). These biochemical and morphological changes can also be obtained in primary cultures as well as in oncogene transformed granulosa cell lines established recently in our laboratory. A growing body of evidence suggests that plasticity of the cytoskeleton plays a major role in the biochemical and morphological differentiation of granulosa cells as well as in other steroidogenic cells. © 1994 Wiley‐Liss, Inc.