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Role of growth factors and their receptors in proliferation of microvascular endothelial cells
Author(s) -
Suhardja Agustinus,
Hoffman Howard
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10245
Subject(s) - receptor , fibroblast growth factor receptor , angiogenesis , growth factor receptor inhibitor , fibroblast growth factor , cancer research , receptor tyrosine kinase , tyrosine kinase , platelet derived growth factor receptor , biology , microbiology and biotechnology , vascular endothelial growth factor , growth factor receptor , cell growth , growth factor , epidermal growth factor , vegf receptors , biochemistry
Investigations over the last decade have established the essential role of growth factors and their receptors during angiogenesis. The biological significance of VEGF, EGF, and bFGF is mediated by their receptors, which belong to the family of tyrosine kinase receptors: Flt‐1 (VEGFR‐1), KDR (VEGFR‐2), EGFR, FGFR‐1, FGFR‐2, FGFR‐3, and FGFR‐4. Deeper understanding of the mechanism of activation of these growth factor receptors has allowed the development of a new pharmacological strategy aimed at controlling cancer cell proliferation. The results of a large body of preclinical as well as early clinical studies conducted suggest that targeting the growth factor receptors could represent a significant contribution to cancer therapy. Microsc. Res. Tech. 60:70–75, 2003. © 2002 Wiley‐Liss, Inc.