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Hormone regulation of endothelial apoptosis and proliferation in vessel regression and angiogenesis
Author(s) -
Kontogeorgos George,
Kontogeorgou Christi.
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10243
Subject(s) - angiogenesis , stromal cell , endothelial stem cell , microbiology and biotechnology , apoptosis , biology , vascular endothelial growth factor a , cell growth , vascular endothelial growth factor b , programmed cell death , cancer research , vascular endothelial growth factor , vegf receptors , biochemistry , in vitro
Apoptosis and endothelial proliferation represent two adverse events which take place during vessel regression and angiogenesis, respectively. Apoptosis, an intrinsically activated programmed cell death, regulates cell elimination during vessel regression. In contrast, angiogenesis involves endothelial cell proliferation, migration, and vascular formation. Several molecules, including growth factors and cytokines, produced by endothelial cells and by other cells within the vicinity of the capillary network, regulate apoptosis and angiogenesis. Hormones and endocrine peptides acting via specific receptors located on the endothelial and perivascular stromal cells also have been found to be involved in the regulation of these two major antagonistic processes. The need for a better understanding of the mechanisms involved in hormone regulation of endothelial cell during apoptosis and angiogenesis is of great importance. The accumulating knowledge of hormone regulation may contribute to the introduction of new therapeutic strategies targeting the endothelial cells. Microsc. Res. Tech. 60:59–63, 2003. © 2002 Wiley‐Liss, Inc.