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Effects of loud noise exposure on mouse myocardium: A comparison with the rat
Author(s) -
Gesi Marco,
Lenzi Paola,
Fornai Francesco,
Ferrucci Michela,
Soldani Paola,
Pellegrini Antonio,
Paparelli Antonio
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10185
Subject(s) - noise exposure , medicine , mitochondrion , stressor , biology , stimulus (psychology) , receptor , endocrinology , microbiology and biotechnology , neuroscience , audiology , psychology , hearing loss , psychotherapist
Loud noise is an environmental stressor of everyday life, which affects different organs and apparati, in particular the cardiovascular system. We have already reported that noise exposure produces significant alterations in the rat myocardium, consisting of mitochondrial damage, which is evident as lysis of the cristae and dilution of the matrix. Since there are high similarities between mouse and human species, the aim of our study was to investigate the effects of acute noise exposure on the mouse heart. We found that noise exposure affects mouse myocardium at similar subcellular sites to those already described in the rat; nonetheless, quantitative analysis of the percentage of altered mitochondria in both species disclosed a clear difference between mouse and rat myocardium, which strongly suggests a different sensitivity to noise stimulus. We hypothesize that the species differences on the extent of myocardial alterations here observed might be due to the zonal pattern of cardiac noradrenergic receptors, which should be the final effectors for noise‐induced myocardial changes. Microsc. Res. Tech. 59:131–135, 2002. © 2002 Wiley‐Liss, Inc.