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Expression and regulatory role of receptors for vasoactive intestinal peptide in bone cells
Author(s) -
Lundberg Pernilla,
Lerner Ulf H.
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10124
Subject(s) - vasoactive intestinal peptide , receptor , microbiology and biotechnology , neurotrophin , periosteum , neuropeptide , bone cell , biology , bone marrow , medicine , endocrinology , chemistry , anatomy , immunology , biochemistry
An intense network of nerve fibers can be demonstrated in skeletal tissues, not only in the periosteum but also within cortical bone, growth plate, and bone marrow. This neuro‐osteogenic network expresses a restricted number of signalling molecules, including neuropeptides, neurotransmitters, and neurotrophins. Several lines of evidence indicate that receptors for these molecules are present on bone cells and that activation of these receptors leads to changes in bone cell activities. In addition, deletion of signalling molecules has been shown to alter bone metabolism. In the present review, these studies are summarized with a focus on distribution and effects of vasoactive intestinal peptide. Microsc. Res. Tech. 58:98–103, 2002. © 2002 Wiley‐Liss, Inc.