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Response of donor and recipient cells after transplantation of cells to the ligament and tendon
Author(s) -
Hildebrand Kevin A.,
Jia Fengyan,
Woo Savio L.Y.
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10114
Subject(s) - mesenchymal stem cell , tendon , transplantation , ligament , wound healing , stem cell , gene transfer , tissue engineering , genetic enhancement , microbiology and biotechnology , medicine , anatomy , pathology , biology , gene , biomedical engineering , surgery , biochemistry
Abstract The mechanical properties of healing ligaments and tendons are not comparable to those of normal tissue. To improve the quality of the ligament healing, therapeutic strategies include gene transfer or placement of mesenchymal stem cells at the healing site. Studies show that marker genes, growth factors, and antisense oligonucleotides can be delivered to both normal and healing ligaments and tendons by gene transfer. Cells with and without genetic modification have been successfully transplanted to ligaments and tendons and remain viable. Tendon healing can be improved using collagen gel implants seeded with autologous mesenchymal stem cells. Even though these early results are encouraging, more work is required regarding the response of the recipient site to donor cells or vectors. Microsc. Res. Tech. 58:34–38, 2002. © 2002 Wiley‐Liss, Inc.