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Role of cell cycle molecules in the pathophysiology of glomerular epithelial cells
Author(s) -
Nagata Michio,
Shu Yujing,
Tomari Shinsuke
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10074
Subject(s) - podocyte , microbiology and biotechnology , transdifferentiation , cell cycle , mesenchyme , biology , cell , mesenchymal stem cell , stem cell , endocrinology , kidney , biochemistry , proteinuria
The postmitotic characteristics of podocytes are the basis for the structural assembly and central function (filtration) of the glomeruli. Persistent cell cycle quiescence is required for stability in these cells. In cells of the podocyte lineage, transdifferentiation from the metanephric mesenchyme to mature podocytes is closely associated with tight regulation of the expression of cell cycle molecules. This cell cycle control in podocytes acts as a safeguard for the glomeruli; however, deregulation of this system might result in structural deterioration. This article focuses on the expression of cell cycle molecules in podocyte differentiation and pathology. Microsc. Res. Tech. 57:203–207, 2002. © 2002 Wiley‐Liss, Inc.