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Multiple roles of adrenomedullin revealed by animal models
Author(s) -
Caron Kathleen M.,
Smithies Oliver
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10046
Subject(s) - adrenomedullin , biology , gene , computational biology , context (archaeology) , gene expression , function (biology) , bioinformatics , genetics , receptor , paleontology
The newly identified adrenomedullin ( AM ) gene codes for a potent, highly conserved vasodilator that is expressed in many tissues. Many biological functions have been ascribed to AM based on its broad expression pattern and numerous in vitro studies, and it is currently viewed as a multifunctional peptide hormone. Recent advances in gene manipulation have permitted the development of experimental animal systems to help distinguish between gene causes and effects in the context of otherwise normal physiology, and so the normal biological function of the AM gene can be studied within the intact physiological milieu of a whole animal. In this review article, we summarize the recent findings from three different types of genetic experiments involving the AM gene. Microsc. Res. Tech. 57:55–59, 2002. © 2002 Wiley‐Liss, Inc.