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Gene expression in the supraoptic nucleus
Author(s) -
Ueta Yoichi,
Levy Andrew,
Lightman Stafford L.
Publication year - 2002
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/jemt.10020
Subject(s) - supraoptic nucleus , vasopressin , oxytocin , nucleus , gene expression , neuropeptide , nitric oxide synthase , biology , arginine , gene , receptor , endocrinology , microbiology and biotechnology , chemistry , medicine , nitric oxide , biochemistry , amino acid
The magnocellular neurosecretory cells (MNCs) in the supraoptic nucleus (SON) express multiple kinds of genes, including not only the classical hormones arginine vasopressin (AVP) and oxytocin (OXT), but also other physiologically active substances including neuropeptides, their receptors, and nitric oxide (NO) synthase, the rate‐limiting enzyme in the synthesis of NO under physiological condition. For example, osmotic stimuli such as dehydration and chronic salt loading cause a wide range of changes of the expression levels of the genes and marked induction of the expression of the genes in the SON. The expression of the NO synthase gene in the SON under physiological conditions is reviewed. Microsc. Res. Tech. 56:158–163, 2002. © 2002 Wiley‐Liss, Inc.