Premium
Stem cell in neurodegenerative disorders; an emerging strategy
Author(s) -
AhaniNahayati Milad,
Shariati Ali,
Mahmoodi Mahnaz,
Olegovna Zekiy Angelina,
Javidi Kamran,
Shamlou Somayeh,
Mousakhani Akbar,
Zamani Majid,
Hassanzadeh Ali
Publication year - 2021
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1002/jdn.10101
Subject(s) - stem cell , neuroscience , induced pluripotent stem cell , neural stem cell , mesenchymal stem cell , amyotrophic lateral sclerosis , regenerative medicine , progenitor cell , stem cell therapy , biology , context (archaeology) , adult stem cell , medicine , cellular differentiation , embryonic stem cell , disease , pathology , microbiology and biotechnology , genetics , paleontology , gene
Neurodegenerative disorders are a diversity of disorders, surrounding Alzheimer's (AD), Parkinson's (PD), Huntington's diseases (HD), and amyotrophic lateral sclerosis (ALS) accompanied by some other less common diseases generally characterized by either developed deterioration of central or peripheral nervous system structurally or functionally. Today, with the viewpoint of an increasingly aging society, the number of patients with neurodegenerative diseases and sociomedical burdens will spread intensely. During the last decade, stem cell technology has attracted great attention for treating neurodegenerative diseases worldwide because of its unique attributes. As acknowledged, there are several categories of stem cells being able to proliferate and differentiate into various cellular lineages, highlighting their significance in the context of regenerative medicine. In preclinical models, stem cell therapy using mesenchymal stem/stromal cells (MSCs), hematopoietic stem cells (HSCs), and neural progenitor or stem cells (NPCs or NSCs) along with pluripotent stem cells (PSCs)‐derived neuronal cells could elicit desired therapeutic effects, enabling functional deficit rescue partially. Regardless of the noteworthy progress in our scientific awareness and understanding of stem cell biology, there still exist various challenges to defeat. In the present review, we provide a summary of the therapeutic potential of stem cells and discuss the current status and prospect of stem cell strategy in neurodegenerative diseases, in particular, AD, PD, ALS, and HD.