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Acrobatic exercise recovers object recognition memory impairment in hypoxic‐ischemic rats
Author(s) -
Almeida Wellington,
Confortim Heloísa Deola,
Deniz Bruna Ferrary,
Miguel Patrícia Maidana,
Vieira Milene Cardoso,
Bronauth Loise,
Santos Adriana Souza,
Bertoldi Karine,
Siqueira Ionara Rodrigues,
Pereira Lenir Orlandi
Publication year - 2021
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1002/jdn.10075
Subject(s) - synaptophysin , striatum , neuroplasticity , hippocampus , neuroscience , hippocampal formation , memory impairment , psychology , medicine , cognition , immunohistochemistry , dopamine
Neonatal hypoxia‐ischemia (HI) can lead to cognitive impairments and motor dysfunction. Acrobatic exercises (AE) were proposing as therapeutic option to manage HI motor deficits, however, the cognitive effects after this treatment are still poorly understood. Therefore, we evaluated the effects of AE protocol on memory impairments and brain plasticity markers after Rice–Vannucci HI rodent model. Wistar rats on the 7th postnatal day (PND) were submitted to HI model and after weaning (PND22) were trained for 5 weeks with AE protocol, then subsequently submitted to cognitive tests. Our results showed recovery in novel object recognition (NOR) memory, but not, spatial Morris Water Maze (WM) memory after AE treatment in HI rats. BDNF and synaptophysin neuroplasticity markers indicate plastic alterations in the hippocampus and striatum, with maintenance of synaptophysin despite the reduction of total volume tissue, besides, hippocampal HI‐induced ipsilateral BDNF increased, and striatum contralateral BDNF decreased were noted. Nevertheless, the exercise promoted functional recovery and seems to be a promising strategy for HI treatment, however, future studies identifying neuroplastic pathway for this improvement are needed.