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Benefits of hypothermia in neonatal arterial ischemic strokes: A preclinical study
Author(s) -
Chevin Mathilde,
Chabrier Stéphane,
Dinomais Mickaël,
Bedell Barry J.,
Sébire Guillaume
Publication year - 2020
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1002/jdn.10022
Subject(s) - neuroprotection , medicine , hypothermia , ischemia , putamen , magnetic resonance imaging , hypoxia (environmental) , positron emission tomography , hypoxic ischemic encephalopathy , cardiology , anesthesia , encephalopathy , radiology , chemistry , organic chemistry , oxygen
Background There is currently no targeted treatment available for neonatal arterial ischemic strokes (NAIS). Epidemiological studies demonstrated that perinatal infection/inflammation, peripartum hypoxia, and occlusion of the internal carotid tree are the main determinants of NAIS. The well‐established benefit of therapeutic hypothermia (HT) in neonatal encephalopathy due to diffuse hypoxia‐ischemia provides a rationale for the potential use of HT as a neuroprotective strategy in NAIS. Methods We used a rat model to reproduce the most prevalent human physiopathological scenario of NAIS. The neuroprotective effect of HT was measured by morphometric magnetic resonance imaging, [ 18 F] fluorodeoxyglucose (FDG) metabolic activity by positron emission tomography/computed tomography, and behavioral tests. Results HT (a) prevented the occurrence of 44% of NAIS, (b) reduced the volume of strokes by 37%, (c) enhanced [ 18 F] FDG metabolic activity within the territory of the occluded carotid artery, and (d) improved motor behavior. Both morphometric and metabolic techniques showed consistently that HT provided a neuroprotective effect located in the motor cortex, hippocampus, and caudate‐putamen. Conclusion Through combining anatomical, metabolic imaging, and behavioral studies, our study provides evidence of neuroprotective effects of HT in NAIS. These results are potentially translational to human NAIS.