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Brain abnormalities on neuroimaging in Children with Congenital Zika Syndrome in Salvador, Brazil, and its possible implications on neuropsychological development
Author(s) -
Sanders Pereira Pinto Paula,
Almeida Thalita Madeira,
Monteiro Lucas,
Souza Mirela Maisa da Silva,
Alves dos Santos George Anderson,
Cardoso Cristiane Wanderley,
Santos Letícia Marques,
Ribeiro Guilherme Sousa,
Santos Darci Neves
Publication year - 2020
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1002/jdn.10016
Subject(s) - damages , neuropsychology , microcephaly , ventriculomegaly , neuroimaging , cognition , brain damage , neuropsychological assessment , psychology , medicine , pediatrics , developmental psychology , clinical psychology , psychiatry , pregnancy , fetus , biology , political science , law , genetics
Objective To characterize the spectrum of brain damages presented in children affected by Congenital Zika Syndrome (CZS), verify the existence of a co‐occurrence pattern of these damages and discuss possible implications for the neuropsychological development. Methods Descriptive, quantitative, individualized, and cross‐sectional study using secondary sources. We selected 136 children with CZS from the database of the Center of Strategic Information on Health Vigilance of the Municipal Office of Salvador, Brazil. We conducted descriptive and multiple correspondence analyses. Results Among the set of analyzed variables, microcephaly (51.5%), ventriculomegaly (57.4%), and brain calcifications (77.2%) were identified as the most frequent. The multiple correspondence analysis showed that the combination of these three variables (32.4%) was what better represented the spectrum of brain damages in the Central Nervous System. Interpretation Damage in the sensory‐motor, cognitive and language development, as well as neurodevelopmental disorders, are described in the literature as impairments associated, either isolated or combined, with these damages, and it is worth highlighting that, in combined brain damages, impairments tend to be more severe. The findings of this study may contribute to understanding the repercussions of CZS on the neuropsychological development of children affected by the epidemic.