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Morphine consumption during pregnancy exacerbates neonatal hypoxia‐ischemia injury in rats
Author(s) -
Bornavard Morad,
Fanaei Hamed,
Mirshekar Mohammad Ali,
Farajian Mashhadi Farzaneh,
Atashpanjeh Alireza
Publication year - 2020
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1002/jdn.10008
Subject(s) - medicine , morphine , lactation , pregnancy , offspring , neurotrophic factors , hypoxia (environmental) , ischemia , anesthesia , endocrinology , oxidative stress , edema , biology , chemistry , genetics , receptor , organic chemistry , oxygen
Objective Hypoxia‐Ischemia (HI) is the most common cause of death and disability in human infants. The use of opiate in pregnant women affects their children. The aim of this study was to evaluate the effect of morphine consumption during pregnancy and lactation on vulnerability to neonatal HI in rats. Materials and methods Female Wistar rats were randomly assigned into two groups: Group 1‐Rats that did not receive any treatment during pregnancy and lactation and Group 2‐Rats that received morphine during pregnancy and lactation. After delivery, male offspring were divided into four groups including: (a) SHAM, (b) SHAM/Morphine (SHAM/MO), (c) HI, (d) HI/Morphine (HI/MO). Seven days after HI induction, neurobehavioral tests were performed, and then, brain tissue was taken from the skull to measure cerebral edema, infarct volume, inflammatory factors, oxidative stress, and brain‐derived neurotrophic factor (BDNF). Results Total antioxidant capacity (TAC) and BDNF levels in the HI/MO group were significantly lower than HI and SHAM groups. TNF‐α, C‐reactive protein and total oxidant capacity levels in the HI/MO group were significantly higher than HI and SHAM groups. Cerebral edema and infarct volume in the HI/MO group were significantly higher than the HI group. Conclusion Based on the results, morphine consumption during pregnancy and lactation enhanced the deleterious effects of HI injury in pups.