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Normal reference values of left ventricular strain parameters in healthy adults: Real‐life experience from the single‐center three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study
Author(s) -
Nemes Attila,
Kormányos Árpád,
Kalapos Anita,
Domsik Péter,
Gyenes Nándor,
Ambrus Nóra,
Lengyel Csaba
Publication year - 2021
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22940
Subject(s) - medicine , reference values , single center , speckle tracking echocardiography , population , cardiology , prospective cohort study , normal values , radial stress , longitudinal study , pathology , ejection fraction , heart failure , environmental health , physics , finite element method , thermodynamics
A number of studies defined normal reference values of three‐dimensional (3D) speckle‐tracking echocardiography (3DSTE)‐derived left ventricular (LV) strains. The present study aimed to quantify normal reference values of LV strains in healthy adult population in real clinical world settings in different age groups, and to determine age‐ and gender‐dependence of these variables in a high volume single center. Methods The present prospective study included 296 healthy adult subjects. Among them, 124 were excluded due to inferior image quality during the 6‐year recruitment period (2011‐2017). The remaining population was further divided into four subgroups based on age decades. Results While global radial (RS) strain showed an increase‐decrease‐increase pattern with age, circumferential, longitudinal, and area strains (CS, LS, AS, respectively) were nonsignificantly lower in older ages. Only global LV‐LS showed gender‐dependency with higher values in females. Although moderately higher RS and 3DS and lower LS, and AS were observed in males, clear gender‐dependency could not be detected in different age decades. Conclusions This study provides normal reference values of 3DSTE‐derived global, segmental, mean segmental, and regional LV strains in healthy adult subjects based on real‐life clinical experience. Age‐, gender‐, and functional nonuniformity of LV strains were also defined.