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Sonographic features of Rosai‐Dorfman disease in the breast: A case report
Author(s) -
Shin Gi W.,
Park Young M.,
Heo Young J.,
Baek Jin W.,
Lee Yoo J.,
Han Ji Y.,
Park Hayoung
Publication year - 2020
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/jcu.22781
Subject(s) - emperipolesis , medicine , rosai–dorfman disease , sinus histiocytosis with massive lymphadenopathy , histiocyte , pathology , pathological , cd68 , histiocytosis , presentation (obstetrics) , disease , radiology , immunohistochemistry
Rosai‐Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is an uncommon histiocytic disease of the lymph nodes. Extranodal presentation, especially in breast parenchymal tissue, is rare. A 54‐year‐old woman presented with a painful and palpable lump in the right breast. Ultrasonography revealed an irregular, indistinct, hypoechoic mass with a hyperechoic halo. Pathological analysis revealed proliferation of large histiocytes and stromal fibrosis with emperipolesis and positive immunoreactivity for S‐100 and CD68. The clinical and radiologic manifestations of Rosai‐Dorfman disease may vary, and differentiation from other inflammatory diseases and malignancies is challenging; thus, accurate pathological diagnosis plays an important role in appropriate management.